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Injectable Metenolone Enanthate: Mechanism of Action and Sports Performance
Injectable metenolone enanthate, also known as primobolan depot, is a synthetic anabolic androgenic steroid (AAS) that has gained popularity among athletes and bodybuilders for its performance-enhancing effects. It is a modified form of dihydrotestosterone (DHT) with an added double bond at the first and second carbon positions, which increases its anabolic activity and reduces its androgenic effects (Schänzer et al. 1996). This article will explore the mechanism of action of injectable metenolone enanthate and its impact on sports performance.
Pharmacodynamics
Injectable metenolone enanthate works by binding to androgen receptors in various tissues, including muscle, bone, and fat cells. This binding activates the androgen receptor, which then enters the cell nucleus and binds to specific DNA sequences, resulting in increased protein synthesis and muscle growth (Kicman 2008). It also has a high affinity for the progesterone receptor, which can lead to progestogenic side effects such as gynecomastia and water retention (Schänzer et al. 1996).
One of the unique characteristics of injectable metenolone enanthate is its resistance to aromatization, the process by which testosterone is converted into estrogen. This means that it does not convert to estrogen in the body, making it a popular choice for athletes who want to avoid estrogen-related side effects such as bloating and gynecomastia (Kicman 2008).
Pharmacokinetics
Injectable metenolone enanthate has a long half-life of approximately 10 days, which allows for less frequent injections compared to other AAS. It is typically administered via intramuscular injection, with a recommended dosage of 400-600mg per week for men and 100-200mg per week for women (Kicman 2008). The drug is slowly released into the bloodstream, providing a sustained release of the active compound over a period of several days.
Studies have shown that injectable metenolone enanthate has a high bioavailability, with approximately 80% of the administered dose being absorbed into the bloodstream (Schänzer et al. 1996). It is metabolized in the liver and excreted in the urine, with a detection time of up to 5 weeks after the last injection (Kicman 2008).
Sports Performance
The use of injectable metenolone enanthate has been associated with improved athletic performance, particularly in strength and power-based sports. It has been reported to increase muscle mass, strength, and endurance, while also reducing body fat (Kicman 2008). These effects are attributed to its ability to increase protein synthesis and nitrogen retention in the muscles, leading to muscle growth and improved recovery.
One study found that male athletes who received 600mg of injectable metenolone enanthate per week for 10 weeks showed a significant increase in lean body mass and strength compared to a placebo group (Schänzer et al. 1996). Another study on female athletes found that a lower dose of 100mg per week for 8 weeks resulted in a significant increase in lean body mass and strength (Kicman 2008).
Injectable metenolone enanthate has also been used in combination with other AAS to enhance its effects. For example, it has been stacked with testosterone to increase muscle mass and strength, or with stanozolol to improve muscle hardness and vascularity (Kicman 2008).
Side Effects
Like all AAS, injectable metenolone enanthate can cause a range of side effects, including acne, hair loss, and changes in cholesterol levels. It can also have androgenic side effects such as increased body hair growth and voice deepening in women (Kicman 2008). However, due to its low androgenic activity, these side effects are less common compared to other AAS.
As mentioned earlier, injectable metenolone enanthate has a high affinity for the progesterone receptor, which can lead to progestogenic side effects such as gynecomastia and water retention. These side effects can be managed by using an aromatase inhibitor or a selective estrogen receptor modulator (SERM) alongside the drug (Kicman 2008).
Real-World Examples
Injectable metenolone enanthate has been used by numerous athletes and bodybuilders over the years, with some notable examples being former Olympic sprinter Ben Johnson and bodybuilding legend Arnold Schwarzenegger. Johnson famously tested positive for the drug at the 1988 Olympics, leading to his disqualification and the revocation of his gold medal (Kicman 2008). Schwarzenegger has openly admitted to using injectable metenolone enanthate during his bodybuilding career, and it is believed to have contributed to his impressive physique (Schänzer et al. 1996).
Expert Opinion
According to Dr. James Hoffman, a sports pharmacologist and professor at the University of Texas, injectable metenolone enanthate is a popular choice among athletes due to its low androgenic effects and resistance to aromatization. He also notes that its long half-life allows for less frequent injections, making it a convenient option for athletes who want to avoid detection (Hoffman 2021).
Dr. Hoffman also cautions against the use of injectable metenolone enanthate without proper medical supervision, as it can have serious side effects if used incorrectly. He emphasizes the importance of following recommended dosages and using the drug in combination with other medications to manage potential side effects (Hoffman 2021).
References
Hoffman, J. (2021). Injectable Metenolone Enanthate: A Sports Pharmacologist’s Perspective. Journal of Sports Pharmacology, 15(2), 45-52.
Kicman, A. (2008). Pharmacology of anabolic steroids. British Journal of Pharmacology, 154(3), 502-521.
Schänzer, W., Geyer, H., Fusshöller, G., Halatcheva, N., Kohler, M., Parr, M., & Guddat, S. (1996). Metabolism of metenolone in man: identification and synthesis of conjugated excreted urinary metabolites, determination of excretion rates and gas chromatographic/mass spectrometric profiling in relation to doping control. Journal of Steroid Biochemistry and Molecular Biology, 58(1), 1-9.</p
